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AMEX Biotech Index (BTK)

Overview:
The American Stock Exchange Biotech Index (BTK) is the benchmark index for the Biotechnology industry. This index was started on October 18, 1991 with a value of 200.00. The index broke below 100 several times prior to 1999 and then peaked during 2000 when it briefly reached 800.

Composition:
The BTK is comprised of 17 firms that are chosen to represent the Biotech sector. The index is relatively unusual in that it is equal-dollar weighted. This means that each stock receives the same weighting in the index. The index is rebalanced four times per year to maintain continuity and to keep any stock from dominating the index's value.

The table below lists the components of the Biotech Index along with the weighting that each stock carries in the index (data as of August 2004):

Company Symbol % of Index
Protein Design Labs PDLI 6.5%
Chiron CHIR 6.5%
Enzon Pharmaceuticals ENZN 6.3%
Gilead Sciences GILD 6.3%
Genzyme GENZ 6.2%
MedImmune MEDI 6.2%
Biogen IDEC BIIB 6.1%
Cephalon CEPH 6.1%
Amgen AMGN 6.1%
Celgene CELG 5.8%
Millennium Pharmaceuticals MLNM 5.7%
Celera Genomics CRA 5.7%
Genentech DNA 5.5%
Affymetrix AFFX 5.5%
Human Genome Sciences HGSI 5.5%
Vertex Pharmaceuticals VRTX 5.3%
Invitrogen IVGN 4.7%

Positives:
The Biotech Index is an excellent choice for investors who wish to track the performance of the Biotech sector apart from the broad market. Although it has been extremely volatile, the Biotech sector has historically outperformed the overall market, so there is a large amount of interest in this area.

Drawbacks:
Many investors do not like the fact that all of the Biotech Index's component stocks are equally weighted. This may distort the index's overall returns because a handful of small companies could have a larger impact on performance than some of the industry's largest players, such as Amgen (AMGN) and Genentech (DNA). The index is also somewhat narrowly focused because it only holds 17 firms out of the hundreds of companies that operate in this sector.

How can I trade/invest in this index?
You can invest in the Biotech Index through many different options, futures and ETFs. However, our favorite way to trade this index is through the Merrill Lynch Biotech HOLDR (BBH). This fund is relatively liquid and carries a very low management fee of $0.08 per share per year, which equates to an expense ratio of less than 0.10% at current prices. This fund has also historically been less volatile than other funds that attempt to track the Biotech Index, even though it is dominated in composition by Biotech giants Amgen (AMGN) and Genentech (DNA). The iShares Biotech fund (IBB) is another tempting choice because it too is widely traded and contains virtually all Biotech firms (over 100). However, it does have higher historical volatility than BBH.

Additional Information: 
AMEX Biotech Index - ^BTK 
Merrill Lynch Biotech HOLDR (BBH)  
iShares Nasdaq Biotech Index Fund (IBB)  


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